All-you-can-eat charcuterie and cheese at Venissimo Cheese Del Mar KUSI Newsroom, February 15, 2018 Posted: February 15, 2018 KUSI Newsroom Categories: Local San Diego News FacebookTwitter 00:00 00:00 spaceplay / pause qunload | stop ffullscreenshift + ←→slower / faster ↑↓volume mmute ←→seek . seek to previous 12… 6 seek to 10%, 20% … 60% XColor SettingsAaAaAaAaTextBackgroundOpacity SettingsTextOpaqueSemi-TransparentBackgroundSemi-TransparentOpaqueTransparentFont SettingsSize||TypeSerif MonospaceSerifSans Serif MonospaceSans SerifCasualCursiveSmallCapsResetSave SettingsFree wine and all-you-can-eat cheese and charcuterie and it’s all part of Venissimo Cheese Happy Hour Extravaganza.KUSI’s Ginger Jeffries was LIVE with all the details.
WILMINGTON, MA — Below is advice from the Wilmington Board of Health published in the most recently Town Topics newsletter:Mosquito and tick season is upon us, the Board of Health would like to remind residents to take precautions to reduce their risk of exposure to mosquitoes and ticks.MOSQUITOES – Try to avoid outdoor activity during times of day with increased mosquito activity, which is dawn and dusk. Use mosquito repellents containing an EPA-approved active ingredient such as DEET.Residents should wear long sleeved clothing to reduce mosquito access to skin and remove any standing water in your yard, including children’s toys, birdbaths, pots and planters.Wilmington is part of the Central Massachusetts Mosquito Control Project and routine spraying and larvicide treatment is conducted throughout the summer.TICKS – Ticks are prevalent in Wilmington. Ticks like damp, shady, brushy, leafy areas. If you have been in an area where ticks might be present, it is important to check yourself, your family and your pets for ticks every day. Use repellents that contain DEET on your exposed skin and those that contain permethrin on your clothes. When spending time outside, if weather permits, wear long-sleeved, light colored shirts and long pants tucked into your socks.Keep the grass cut short and remove piles of leaves and brush. Talk to your veterinarian about the best ways to protect your pets and livestock from ticks.If you find a tick on yourself, remove it carefully as soon as possible. If you develop a rash or other signs of illness following a tick bite, be sure to contact your health care provider immediately. If you are looking into preventative tick control, check out tick tubes, which may be found online. They work great ridding areas of deer ticks only. Remember deer ticks are the ones that transmit Lyme Disease. If you have been bitten by a tick, log on to the Board of Health website for links to get the ticks tested.Like Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email firstname.lastname@example.org.Share this:TwitterFacebookLike this:Like Loading… RelatedWilmington Board Of Health Offers Advice On Mosquitoes & TicketsIn “Government”Wilmington Board Of Health Urges Residents To Use Caution As Mosquitos Test Positive For EEE In AndoverIn “Government”Request A Free Mosquito Spraying From Central Mass. Mosquito Control Project This SeptemberIn “Government”
BNP senior leader Moudud Ahmed. Prothom Alo File PhotoBNP standing committee member Moudud Ahmed alleged that policemen barred him from leaving his house in Manikpur village of Companiganj upazila in Noakhali district to exchange greeting with supporters on the Eid day, Saturday.Police, however, denied the allegation citing ‘the blockade was for security reasons’, reports UNB.The Bangladesh Nationalist Party standing committee member Moudud told newsmen that it has been proved that this government has become isolated from people and also being feared to face mass people.”So, policemen were deployed in front of my house in the morning and they barred me from coming out of my home,” he added.”I asked police to arrest me if I did anything wrong or let me go out, but they were firm about not allowing me to go outside,” said the senior BNP leader.Moudud said he spoke to Companiganj police station officer-in-charge and superintendent of police in Noakhali Md Ilias Sharif. Both denied him permission to go out, he added.When contacted, Md Ilias Sharif said, “Moudud Ahmed is a senior political leader. We deployed police in front of his house considering his security.”Rabiul Islam, sub-inspector (investigation) of Companiganj police station, who was on duty in front of Moudud’s house, said police were deployed following an intelligence report that he might face problems if he went out of home just before evening.
Randi Weingarten tries to deliver a teddy bear and other items for children to federal agents at the port-of-entry, Tuesday on 26 June 2018, in Fabens, Texas, along the international border where immigrant children are being held. The group tried to deliver items to the children housed in tents at the facility but were turned away. Photo: APA judge in California on Tuesday ordered US border authorities to reunite separated families within 30 days, setting a hard deadline in a process that has so far yielded uncertainty about when children might again see their parents.If children are younger than 5, they must be reunified within 14 days of the order issued Tuesday by US district judge Dana Sabraw in San Diego. Sabraw, an appointee of President George W. Bush, also issued a nationwide injunction on future family separations, unless the parent is deemed unfit or doesn’t want to be with the child. He also requires the government provide phone contact between parents and their children within 10 days.More than 2,000 children have been separated from their parents in recent weeks and placed in government-contracted shelters – hundreds of miles away, in some cases – under a now-abandoned policy toward families caught illegally entering the USAmid an international outcry, Trump last week issued an executive order to stop the separation of families and said parents and children will instead be detained together. A Department of Homeland Security statement over the weekend on reuniting families only seemed to sow more confusion.”The facts set forth before the Court portray reactive governance_responses to address a chaotic circumstance of the Government’s own making,” Sabraw wrote. “They belie measured and ordered governance, which is central to the concept of due process enshrined in our Constitution.”The ruling was a win for the American Civil Liberties Union, which filed the lawsuit in March involving a 7-year-old girl who was separated from her Congolese mother and a 14-year-old boy who was separated from his Brazilian mother.”Tears will be flowing in detention centers across the country when the families learn they will be reunited,” said ACLU attorney Lee Gelernt.The Justice and Homeland Security Departments did not immediately respond to requests for comment late Tuesday.It’s not clear how border authorities will meet the deadline. Health and Human Services Secretary Alex Azar told Congress on Tuesday that his department still has custody of 2,047 immigrant children separated from their parents at the border. That is only six fewer children than the number in HHS custody as of last Wednesday. Democratic senators said that wasn’t nearly enough progress.Under questioning, Azar refused to be pinned down on how long it will take to reunite families. He said his department does extensive vetting of parents to make sure they are not traffickers masquerading as parents.Also challenging will be the requirement the judge set on phone contact.At a Texas detention facility, immigrant advocates complained that parents have gotten busy signals or no answers from a 1-800 number provided by federal authorities to get information about their children.Attorneys have spoken to about 200 immigrants at the Port Isabel detention facility near Los Fresnos, Texas, since last week, and only a few knew where their children were being held, said Simon Sandoval-Moshenberg of the Legal Aid Justice Center in Virginia.”The US government never had any plan to reunite these families that were separated,” Sandoval-Moshenberg said, and now it is “scrambling to undo this terrible thing that they have done.”A message left for HHS, which runs the hotline, was not immediately returned.Many children in shelters in southern Texas have not had contact with their parents, though some have reported being allowed to speak with them in recent days, said Meghan Johnson Perez, director of the Children’s Project for the South Texas Pro Bono Asylum Representation Project, which provides free legal services to minors.”Things might be changing now. The agencies are trying to coordinate better,” she said. “But the kids we have been seeing have not been in contact with the parents. They don’t know where the parent is. They’re just distraught. Their urgent need is just trying to figure out, ‘Where is my parent?'”The decision comes as 17 states, including New York and California, sued the Trump administration Tuesday to force it to reunite children and parents. The states, all led by Democratic attorneys general, joined Washington, DC, in filing the lawsuit in federal court in Seattle, arguing that they are being forced to shoulder increased child welfare, education and social services costs. The Justice Department did not immediately respond to a request for a comment on the multistate lawsuit.”The administration’s practice of separating families is cruel, plain and simple,” New Jersey Attorney General Gurbir Grewal said in a statement. “Every day, it seems like the administration is issuing new, contradictory policies and relying on new, contradictory justifications. But we can’t forget: The lives of real people hang in the balance.”In a speech before the conservative Criminal Justice Legal Foundation in Los Angeles, U.S. Attorney General Jeff Sessions defended the administration for taking a hardline stand on illegal immigration and said the voters elected President Donald Trump to do just that.”This is the Trump era,” he said. “We are enforcing our laws again. We know whose side we are on – so does this group – and we’re on the side of police, and we’re on the side of the public safety of the American people.”After expressing reluctance in May to get too deeply involved in immigration enforcement decisions, the judge who issued Tuesday’s ruling was clearly influenced by Trump’s reversal last week and the Homeland Security Department’s statement on its family reunification plan Saturday night, which, he said, left many questions unanswered.”This situation has reached a crisis level. The news media is saturated with stories of immigrant families being separated at the border. People are protesting. Elected officials are weighing in. Congress is threatening action,” he wrote.Outraged by the family separations, immigrant supporters have led protests in recent days in states such as Florida and Texas. In Los Angeles, police arrested 25 demonstrators at rally Tuesday ahead of Sessions’ address.Outside the U.S. attorney’s office, protesters carried signs reading, “Free the children!” and “Stop caging families.” Clergy members blocked the street by forming a human chain. Police handcuffed them and led them away.Later, protesters gathered outside the hotel where Sessions gave his speech. As the attorney general’s motorcade arrived, the crowd chanted, “Nazi, go home.”Weissert reported from Harlingen, Texas. Associated Press writers Ricardo Alonso-Zaldivar in Washington; Gene Johnson in Seattle; Robin McDowell in Austin, Texas; Amy Taxin in Santa Ana, California; and John Antczak in Los Angeles contributed to this report.
Share 00:00 /01:08 – / 3Woodlands Express is a commuter bus service that’s operated by The Woodlands Township, with the help of a federal transit grant. About 2,700 riders a day use the service to get from The Woodlands to downtown Houston. It also stops in the Med Center and Greenway Plaza. But when the buses head back to Montgomery County, they’re empty. To fill those seats, The Woodlands Township Board of Directors has approved a new reverse-commuting program. The Woodlands Director of Community Relations Nick Wolda says the buses will now start carrying people from Houston to the suburbs.“There’s really no risk on our part as far as the financial risk because these are buses already coming back,” says Wolda. But once you get riders to The Woodlands, how do you get them to the places where they work? Wolda says they plan to discuss that with some of the area’s major employers. “Those are things we’ll be working through over the next few weeks,” adds Wolda. “And we plan to launch this service once we develop and work out a lot of these details.” Woodlands Express is planning to start the reverse commuting program after the first of the year. The fare for a round-trip is currently $13. Listen X To embed this piece of audio in your site, please use this code:
The proposed model of cytosolic mobility: (Red box) objects (red spheres) larger than the pore size of the cytoskeleton (50-75 nm) are trapped in a viscoelastic medium and experience restricted diffusion, (green box) if objects are perfectly inert they diffuse freely without hindrance due to obstacles, (purple box) when objects interact with intracellular components diffusion is slowed down but remains Brownian, (yellow box) if interactions increase to the point that immobilization time is longer than the time of observation, the diffusion is significantly slowed down to become anomalous, known as subdiffusion. Credit: Nature Materials (2018) doi: 10.1038/s41563-018-0120-7 Play Representative videos of 25 nm fluorescently labelled NPs diffusing in HeLa cells after pinocytic loading for single-particle tracking experiments. Top panel: unburst vesicles with encapsulated NPs; particles in the intact vesicles move very fast and cannot be tracked individually. Bottom panel: examples of typical regions of interest selected for single-particle tracking analysis of NPs, systematically excluding the unburst vesicles. Behavioral difference of free versus encapsulated NPs ensured a reliable discrimination between the two cases. Images were acquired every 10 ms; video was encoded at 30 frames per second (fps). Scale bar 1 µm. Credit: Nature Materials (2018), doi: 10.1038/s41563-018-0120-7. A brief osmotic shock enabled the dispersion of NPs into the cytoplasm. The NP’s diffusion-based exploration of the cell’s interior was monitored by extensive single-particle tracking experiments. Using this approach, a variety of NP surface modifications and particle sizes ranging from 15 to 75 nm were observed to interact with the surroundings for pronounced diffusion anomalies. , Cell © 2018 Phys.org The experimental data were also explained with a minimal model based on continuous-time random walks, where particles were described to take power-law-distributed rests between periods of free diffusion motion. With this approach, the findings on MSD could be reproduced and captured as particle trajectories. Future work is required to explore if these results also apply to crowds of one to 10 nm-sized macromolecules in cells. Gaining an understanding of how anomalous random walks can be altered when modifying non-equilibrium conditions in cells (such as changed metabolic states) will keep both experimentalists and theorists busy. Overall, the researchers proposed a unified framework to describe the dynamics of diffusion related to nanosized objects in the cell cytoplasm. The study also provided a quantitative benchmarking tool to design perfectly inert NPs that could diffuse within cells unhindered by obstacles, and defined them as “lone maze runners.” Such insights may become crucial to design intracellular drug delivery pathways to easily reach molecular targets within cells in the future. Citation: Maze runners and square dancers: Cytosolic diffusion of nanosized objects in mammalian cells (2018, August 15) retrieved 18 August 2019 from https://phys.org/news/2018-08-maze-runners-square-dancers-cytosolic.html Cells are complex, multi-compartmentalized entities of matter enclosed with a variety of membrane-bound organelles ranging from the microscale (µm) down to the nanoscale (nm) in diameter. These structures intermingle in a crowded aqueous phase known as the cytoplasm, within which diffusion deviates from Brownian motion. Understanding the concept of “cell crowding” and the impact on intracellular mobility can enable controlled diffusion within cells for improved drug delivery and other medical applications. The eukaryotic cytoplasm is a biphasic poroelastic (fluid and solid interaction) medium, containing a fluid phase (cytosol with water and soluble proteins) and a solid phase (cytoskeleton and other organelles). PausePlay% buffered00:0000:00UnmuteMuteDisable captionsEnable captionsSettingsCaptionsDisabledQuality0SpeedNormalCaptionsGo back to previous menuQualityGo back to previous menuSpeedGo back to previous menu0.5×0.75×Normal1.25×1.5×1.75×2×Exit fullscreenEnter fullscreen Explore further , Reports on Progress in Physics More information: Fred Etoc et al. Non-specific interactions govern cytosolic diffusion of nanosized objects in mammalian cells, Nature Materials (2018). DOI: 10.1038/s41563-018-0120-7 Matthias Weiss. A tale about square dancers and maze runners, Nature Materials (2018). DOI: 10.1038/s41563-018-0126-1A. Einstein. Über die von der molekularkinetischen Theorie der Wärme geforderte Bewegung von in ruhenden Flüssigkeiten suspendierten Teilchen, Annalen der Physik (2007). DOI: 10.1002/andp.19053220806 Alice B. Fulton. How crowded is the cytoplasm?, Cell (2004). DOI: 10.1016/0092-8674(82)90231-8 Felix Höfling et al. Anomalous transport in the crowded world of biological cells, Reports on Progress in Physics (2013). DOI: 10.1088/0034-4885/76/4/046602 O. Bénichou et al. Geometry-controlled kinetics, Nature Chemistry (2010). DOI: 10.1038/nchem.622 Experiments conducted with tracers on intracellular motion have typically revealed both Brownian and subdiffusive motion (or anomalous diffusion). High concentrations of macromolecules in the cytoplasm described as “obstructive molecular crowding” and biochemical interactions (electrostatic or hydrophobic) naturally affect the mobility of intracellular tracers. As a result, a fundamental question has remained unresolved: Can a unified framework account for the large variability of behaviors observed in cytosolic diffusion? Now writing in Nature Materials, Fred Etoc and colleagues have used single-particle tracking of fluorescent nanoparticle (NP) tracers to observe and propose a unified framework that describes the diffusion dynamics of nanosized objects in the eukaryotic cell cytoplasm.The researchers demonstrate:Inert objects were unaffected by obstructive molecular crowding to show Brownian motion, diffusing in a medium of low viscosity—if they were below approximately 75 nm in size. The researchers metaphorically compared them to “maze runners”Tracers that were approximately 25 nm in size but with increased non-specific interactions slowed down diffusion by three orders of magnitude, to gradually become anomalous and were compared to “square dancers”The strength of non-specific interactions is captured into a single parameter using a simple continuous time random walk (CTRW) model, a textbook model that describes the random walk performed by diffusing particles. By fixing a few basic properties of the random walk, it was possible to observe that diffusing particles explored an area (mean square displacement – MSD) that grew linearly in time. To define the phenomenon of intracellular motion experimentally, Etoc and co-workers hijacked a cellular entry gate known as the pinocytosis pathway (observed with vesicle formation to transport biological materials), to import functionalized and fluorescently labelled nanoparticles (NPs) in to living HeLa cells. Cytoplasmic diffusion of individual NPs (20 to 50 NPs per cell) was recorded by time-lapse microscopy and quantified using single-particle tracking analysis. In the cytoplasm of living HeLa cells non-specific interactions mainly contribute to anomalous diffusion. By changing the surface properties of NPs from strong to almost vanishing interactions within the interior of living cells, the trajectories of interacting NPs (square dancers) were shown to exhibit significant anomalous diffusion (indicated by red regions in density plots). In contrast, non-interacting NPs (lonesome maze runners) underwent normal diffusion. Adapted from doi:10.1038/s41563-018-0120-7. Credit: Nature Materials (2018), doi: 10.1038/s41563-018-0126-1. In the study, Etoc et al. estimated mobility at short timescales by computing time averaged MSD at 60 ms, expressed in terms of the diffusion coefficient D60ms To represent the behavior of the whole population of NPs in each condition, the distribution of the parameters α (anomalous exponent) and D60ms arising from each individual trajectory, was presented as a two-dimensional (2-D) density map. Such density plots for hundreds of trajectories and conditions that integrated the results of α and D60ms were summarized elegantly in the findings. , Nature Chemistry The hidden order in DNA diffusion Journal information: Nature Materials This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.